最後更新：2026年10月1日
已完成疫苗接種的動物仍然感染疫苗所針對的疾病。可能原因包括疫苗儲存不當、母源抗體干擾、免疫功能不全或病毒株變異等。需區分真正失效與不當接種。
貓疫苗失效罕見,FIP疫苗效果原本就有爭議
犬小病毒及犬瘟熱疫苗失效偶見,多與接種時機或儲存問題相關
建議：依臨床狀況調整
監測頻率：依病因
[1]Mycotoxins in Broiler Production: Impacts on Growth, Immunity, Vaccine Efficacy, and Food Safety.
[2]Phytochemicals: a promising approach to control infectious bursal disease.
[3]Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic.
[4]Development and evaluation of an attenuated Avibacterium paragallinarum strain as a live vaccine candidate for infectious coryza.
[5]Development of a genotype-matched Newcastle disease DNA vaccine candidate adjuvanted with IL-28b for the control of targeted velogenic strains of Newcastle disease virus in Africa.
[6]WSAVA Guidelines for the vaccination of dogs and cats.
建議數日內就診評估，非立即危及生命但不宜拖延 (evaluation within days recommended, not immediately life-threatening)
預後取決於感染疾病的嚴重程度及宿主免疫狀態。免疫功能正常者即使疫苗失效,症狀通常較輕。
Diagnostic Approach for Vaccine Failure
Thorough history collection; complete physical examination with attention to presenting complaint
CBC, serum chemistry panel, urinalysis; additional tests based on clinical findings
Advanced imaging, specialized testing, or referral based on minimum database findings