AHA inhibits urease thereby reducing production of urea and subsequent urinary concentrations of ammonia, bicarbonate and 10 acetylcysteine carbonate. While the drug does not directly reduce urine pH, by reducing ammonia and bicarbonate production by urease-producing bacteria, it prevents increases in urine pH. The drug may act synergistically with several antimicrobial agents ( _e.g._, carbenicillin, gentamicin, clindamycin, trimethoprim-sulfa or chloramphenicol) in treating some urinary tract infections. The drug’s effects on urinary pH and infection also indirectly inhibit the formation of urinary calculi (struvite, carbonate-apatite).
Acetohydroxamic acid can be used in dogs as adjunctive therapy in some cases of recurrent urolithiasis or in the treatment of persistent urinary tract infections caused by the following bacteria: _E. coli_, _Klebsiella_, _Morganella_ _morganii_, _Staphylococci_ spp., and _Pseudomonas_ _aeruginosa_ . Adverse effects limit its usefulness.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。