商品名:Zinacef*, Zinnat*
A 2nd generation cephalosporin that binds to proteins involved in bacterial cell wall synthesis, thereby decreasing cell wall strength and rigidity, and affecting cell division. Resistant to some bacterial beta-lactamases. As other beta-lactam antibacterials, works in a time-dependent fashion. Cefuroxime axetil is hydrolysed in intestinal mucosa and liver to yield active drug giving oral bioavailability.
Higher activity against many Gram-negative organisms when compared to 1st generation cephalosporins. Good activity against a Z Y X W V U T S R Q P O N M L K J I H G F E D C B A BSAVA Small Animal Formulary 8th edition 67 wider spectrum of Enterobacteriaceae (not Pseudomonas). Many obligate anaerobes also susceptible. It is a time-dependent antimicrobial, so maintaining levels above the MIC are important for efficacy. Limited applications in veterinary species and limited pharmacokinetic data mak
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
執行前必須由獸醫師核對有效成分、鹽型或前驅藥、精確商品與強度基準、物種、感染部位、檢體、病原與菌株、藥敏方法與適用斷點、病患過敏史、腎肝功能、併用藥、監測計畫及法域規則;任一條件未閉合即不得計算或產生處方。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。