商品名：Clomicalm (veterinary preparation) and Anafranil
Tricyclic antidepressant drug (TCA). Used in people to treat anxiety and depression. Action is via inhibition of uptake of serotonin at presynaptic nerve terminals. Beneficial effects may be caused primarily by blocking reuptake of serotonin and modulation of serotonin in areas of the brain that affect anxiety and behavior. Clomipramine has more serotonin-reuptake blocking effects than other TCA drugs. Side effects result from antimuscarinic effects caused by the active metabolite desmethylclomipramine. However, animals produce less of this metabolite than people do.
Like other TCAs, clomipramine is used in animals to treat various behavioral disorders, including obsessive-compulsive disorders (also called canine compulsive disorder) and separation anxiety. In dogs, it has been superior to amitriptyline for treating compulsive disorders; however, it does not appear to be beneficial when used for dominance-related aggression. In cats, with long-term treatment it has been effective for decreasing urine spraying (J Am Vet Med Assoc, 226: 378-382, 2005). It was equally effective as fluoxetine for urine spraying in cats, but treated animals returned to urine ma
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認精確產品、鹽型、有效基質、強度與法域 確認物種、年齡、體重、完整行為診斷與個別化行為計畫 確認癲癇、心血管、青光眼、腸胃蠕動、排尿、肝腎與生殖狀態 核對全部藥品與保健品並由獸醫師制定監測、反應、失敗與停藥計畫
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。