商品名:Panadol, Calpol, Tylenol (USA), Acetaminophen (USAN), Pamol
Antipyretic and analgesic action proposed to be via central inhibition of prostaglandin synthesis (COX-3 variant in CNS) and modulation of serotonergic, cannabinoid, and TRPV1 pathways. Lacks meaningful peripheral COX inhibition, hence minimal anti-inflammatory effect and reduced GI toxicity relative to NSAIDs.
Mild to moderate pain in dogs (often combined with codeine 1-2 mg/kg PO). Useful when NSAIDs are contraindicated (GI ulceration, renal insufficiency). ABSOLUTELY CONTRAINDICATED in cats and ferrets (deficient UGT1A6 glucuronidation → NAPQI accumulation → methemoglobinemia and hepatic necrosis; lethal at ≥10 mg/kg).
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
D0511 Paracetamol 與 D0016 Acetaminophen 是同一活性成分,不得維護第二套劑量。現有 15 mg/kg PO q8h 只是 D0016 已審同成分 WSAVA 範圍的一個端點,沒有獨立產品或第二療程依據;犬 IV 研究與 Pardale-V 複方也不可互換。完成 alias/redirect 前封鎖計算與飼主劑量;貓禁止治療使用。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。