商品名:Propyl-Thyracil, PTU, and generic brands
Antithyroid drug. Propylthiouracil inhibits synthesis of thyroid hormones; specifically, it interferes with conversion of T4 to T3.
Propylthiouracil has been used for the treatment of feline hyperthyroidism. Because of adverse effects, use of propylthiouracil in most cats has been replaced with methimazole or carbimazole. The only remaining indication for propylthiouracil in animals is to treat an acute “thyroid storm” because it rapidly inhibits conversion of T3 to T4, which methimazole does not.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現行權威獸醫資料不建議貓常規使用 PTU,犬研究亦不足;live 50 mg/cat q8h 與 raw 11 mg/kg q12h 衝突,且嚴重免疫性血液風險明確。所有劑量與一般處方輸出均 fail-closed。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。