商品名：Claforan
Cephalosporin antibiotic. Action is similar to other beta-lactam antibiotics, which inhibits synthesis of bacterial cell wall leading to cell death. Cephalosporins are divided into first-, second-, third-, and fourth-generation drugs depending on spectrum of activity. Cefotaxime is a third-generation cephalosporin. Like other third-generation cephalosporins, it has enhanced activity against gram-negative bacilli, especially Enterobacteriaceae, which may be resistant to first- and second- generation cephalosporins, ampicillin derivatives, and other drugs. It is active against Escherichia coli,
Cefotaxime is used when resistance is encountered to other antibiotics or when infection is in the CNS. Because it is injectable, is expensive, and must be administered frequently, it is not used for routine infections in veterinary medicine when other drugs will be active. Although cefotaxime is not FDA approved for use in animals, it is one of the most often used injectable third-generation cephalosporins used in small animals. The use in large animals is uncommon.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
腎功能調整：Extend interval to q8-12h in renal impairment
腎功能調整：Extend interval to q8-12h in renal impairment
腎功能調整：Extend interval to q8-12h in renal impairment
確認活性成分、效價基準、劑型、容器、濃度、重組、稀釋、相容性、保存歷史與實際產品 確認物種、體重、年齡、病況、感染部位、嚴重度、檢體、病原、感受性方法與可適用的判讀標準 區分經驗性與目標性治療，考量地區抗藥性、替代方案、抗菌藥管理及法域 確認頭孢菌素與其他 beta-lactam 過敏史、腎功能、水合、神經風險、生殖狀態及所有併用藥 建立臨床反應、治療失敗、過敏、腸胃、腎臟、神經、二重感染與檢驗干擾的個別監測及失敗處置
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
87%
1 hours
renal