商品名:Mepron
Atovaquone is an antimicrobial agent, an analogue of ubiquinone, that inhibits mitochondrial transport in protozoa by targeting the cytochrome bc1 complex. It also inhibits nucleic acid and ATP synthesis in susceptible cells. Atovaquone is active against protozoa such as Pneumocystitis, for which it is used in people. In cats it is used to treat Cytauxzoon felis. It may not eradicate Cytauxzoon, but it will decrease the parasite burden. In dogs, it has been used to treat Babesia gibsoni. For treating these infections in dogs and cats, it appears to have an additive or synergistic effect when c
In people, atavaquone is an antiprotozoal that is primarily used in individuals who cannot tolerate sulfonamides. In animals, it has been used, often in combination with azithromycin, to treat refractory protozoan diseases and bloodborne pathogens.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
啟用前必須同時鎖定 atovaquone 單方或含 proguanil 複方、商品、濃度、劑型、調劑來源、物種、病原與基因型或菌株、急慢性與嚴重度、診斷方式、途徑、進食與吸收條件、全部組合藥、期間、支持療法、追蹤與清除定義、復發及 cytochrome-b 抗性、胃腸與肝臟等風險、生殖狀態、監測、救援、法域及食物鏈狀態。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。