Alkalinized urine can decrease excretion With potassium citrate products, the following agents may lead to increases in serum potassium levels (inc...
Tetracyclines have increased the bioavailability of digoxin in a small percentage of human patients and caused digoxin toxicity.
May displace MTX from plasma proteins increasing risk for toxicity, but also may reduce MTX absorption and enterohepatic recirculation
Fatal nephrotoxicity has occurred in humans when used with tetracycline; concomitant use with oxytetracycline not recommended
Tetracyclines have caused decreased atovaquone levels
Bismuth containing products can decrease the absorption of orally administered tetracycline products.
Oral calcium can reduce the amount of tetracyclines or fluoroquinolones absorbed from the GI tract; separate dosages by two hours if possible
Divalent or Trivalent Cations⚠️ 中風險
When orally administered, tetracyclines can chelate divalent or trivalent cations that can decrease the absorption of the tetracycline or the other...
Metoclopramide increase the rate and extent of GI absorption
Use with tetracyclines may increase the potential for the occurrence of pseudotumor cerebri (cerebral edema and increased CSF pressure).
The antacids in buffered aspirin may chelate tetracycline products if given simultaneously; space doses apart by at least one hour
Beta-Lactam or Aminoglycoside Antibiotics✅ 低風險
Bacteriostatic drugs, like the tetracyclines, may interfere with bactericidal activity of the penicillins, cephalosporins, and aminoglycosides; the...
Oral calcium-containing products can reduce absorption of fluoroquinolones; if both calcium acetate and one of these antibiotics are required, sepa...
Theoretical antagonism; use together usually not recommended
Concomitant oral sodium bicarbonate may reduce absorption; administer separately
Tetracyclines may depress plasma prothrombin activity and patients on anticoagulant therapy may need dosage adjustment
Zinc salts may chelate oral tetracycline and reduce its absorption; separate doses by at least two hours