商品名:ASA, acetylsalicylic acid, Bufferin, Ascriptin, and many
Nonsteroidal anti-inflammatory drug (NSAID). Anti-inflammatory action is caused by inhibition of prostaglandins. Aspirin binds irreversibly to the cyclo-oxygenase (COX) enzyme in tissues to inhibit synthesis of prostaglandins. At low doses it may be more specific for COX-1 than COX-2. Anti-inflammatory effects are attributed to inhibition of COX, but other anti-inflammatory mechanisms—attributed to salicylates—may also contribute to the anti-inflammatory action, such as inhibition of NF kappa-B. Pharmacokinetics are variable in animals with a half-life that ranges from 1 hour in horses, 6 hour
Aspirin is used as an analgesic, anti-inflammatory, and antiplatelet drug. At low doses, aspirin is a more specific COX-1 selective inhibitor and antiplatelet drug than other NSAIDs. Therefore, low doses have been used in animals specifically to prevent thromboemboli formation. Low doses of aspirin are routinely used for antiplatelet therapy, but aspirin does not provide complete inhibition of platelet stimulation. Addition of other antiplatelet drugs such as clopidogrel (Plavix) Aspirin 53 A provides more effective inhibition. Although aspirin has been available for many years, it is not regi
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現行服務把止痛、抗血栓、眼科與多物種數值混成可執行方案;犬眼科 150–300 mg/kg 還落入公開重複暴露毒性範圍。Aspirin 未核准為通用犬貓獸醫 NSAID,AAHA/AAFP 不建議作犬貓疼痛常規治療;CURATIVE 也無法建立單一犬抗血栓 protocol,且貓心肌病不可單用。雪貂與食用動物數值缺足夠現行證據,FDA 明示牛無核准 aspirin 且不得將未核准產品超標用於食用動物,因此全面封鎖通用計算、處方與飼主劑量。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal