商品名：Fosamax
Bisphosphonate drug. Drugs in this class include pamidronate, risedronate, zolendronate, and etidronate. This is a group of drugs characterized by a germinal bisphosphonate bond. They slow the formation and dissolution of hydroxyapatite crystals. Their clinical use is in their ability to inhibit bone resorption. These drugs decrease bone turnover by inhibiting osteoclast activity, retarding bone resorption, and decreasing the rate of osteoporosis. Alendronate is 100-1000 times more potent than older drugs such as etidronate. Unfortunately, alendronate is poorly absorbed orally (3%-7%), and use of oral formulations in animals may not be effective. In dogs, half-life in plasma is short (1-2 hours), but there is prolonged update bone in which the half-life is 300 days.
Alendronate, like other bisphosphonate drugs, is used in people to treat osteoporosis and treatment of hypercalcemia of malignancy. In animals, alendronate is used to decrease calcium in conditions that cause hypercalcemia, such as cancer and vitamin D toxicosis. It may be helpful for managing neoplastic complications associated with pathologic bone resorption. It also may provide pain relief in patients with pathologic bone disease. Most experimental work performed in dogs has been performed with pamidronate rather than alendronate. Alfaxalone 15 A Instructions for Use When administering oral medication, ensure that the drug is not trapped in the esophagus. Food will significantly reduce oral absorption. Wait at least 30 minutes before feeding. Patient Monitoring and Laboratory Tests Moni
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認活性母體、鈉鹽、水合物、劑型、強度換算、製造者與法域 確認物種、個別適應症、鑑別診斷、腎功能與礦物質基線 完成口腔與牙科風險評估，並建立離子鈣、磷與臨床反應監測 長期使用必須定期重評持續必要性、顎骨病變、疼痛、跛行與非創傷性骨折
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。