商品名：Zometa, Zoledronic acid
Bisphosphonate drug. Zoledronate is zoledronic acid (Zometa). Drugs in this class include pamidronate, etidronate, tiludronate, and alendronate. These drugs are a group of drugs characterized by a germinal aminobisphosphonate bond. They slow the formation and dissolution of hydroxyapatite crystals. Their clinical use resides in their ability to inhibit bone resorption. These drugs decrease bone turnover by inhibiting osteoclast activity, inducing osteoclast apoptosis, retarding bone resorption, and decreasing the rate of osteoporosis. Inhibition of bone resorption is via inhibition of the mevalonate pathway. In dogs, after infusion the half-life was approximately 2.2 hours, with a volume of distribution of 0.28 L/kg.
Zoledronate, like other bisphosphonate drugs, is used to treat refractory hypercalcemia, osteoporosis, and treatment of hypercalcemia of malignancy. In animals, bisphosphonates are helpful for managing neoplastic complications and pain associated with pathologic bone resorption. They also may provide pain relief in patients with pathologic bone disease. It has been used in similar protocols as for pamidronate but has the advantage of a 15-minute infusion IV rather than 2-4 hours for pamidronate.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
在確認 exact product／濃度／active-moiety basis、物種、適應症、輸注液與輸注時間、腎功能與水合狀態、鈣磷鎂狀態、口腔牙科計畫及生殖狀態前，封鎖一般自動劑量計算、處方輸出及飼主可執行劑量。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。