商品名：Lanoxin and Cardoxin
Cardiac inotropic agent. Digoxin increases cardiac contractility and decreases heart rate. The mechanism is via inactivation of cardiac muscle sodium–potassium ATPase and increased intracellular availability of calcium, triggering calcium release from sarcoplasmic reticulum. In addition, neuroendocrine effects include sensitization of baroreceptors, which decreases heart rate by increasing vagal tone. Beneficial effects cardiac effects may be caused by decreased heart rate and suppression of the AV node to inhibit re-entrant cardiac arrhythmias via these neuroendocrine effects.
Digoxin is used in heart failure for inotropic effect and decreased heart rate in dogs, cats, and occasionally other animals. It is used in supraventricular arrhythmias to decrease ventricular response to atrial stimulation via suppresson of the AV node. Digoxin may be used with other drugs for heart failure such as angiotensin- converting enzyme (ACE) inhibitors (e.g., enalapril), diuretics (furosemide), and vasodilators.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
DRUGAPI 尚未提供本藥的劑量審查結論與引用來源。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。