商品名：Diuril
Thiazide diuretic. The thiazide diuretics are used infrequently in veterinary medicine. They include hydrochlorothiazide and chlorothiazide. These drugs are sulfonamide analogs and share similar chemical properties, but the pharmacokinetics have not been very well described in animals. The action of thiazides is to inhibit the Na/Cl cotransporter in the luminal side of the distal tubule. By inhibiting the cotransporter, Na+ and Cl- reabsorption is blocked, leading to sodium and water diuresis. Because the action occurs in the distal tubule, these drugs have less of a diuretic effect (less efficacy) than the loop diuretics.
Chlorothiazide use is not common in animals. In people it is used primarily to treat hypertension. In animals it has been used to treat hypercalciuria (increased calcium in the urine that may lead to urinary calculi). Chlorothiazide inhibits sodium reabsorption in distal renal tubules to produce a more dilute urine. Because it decreases renal excretion of calcium, it also has been used to prevent uroliths containing calcium. Dosage regimens used are derived either empirically or from extrapolation of the human dose. Instructions for Use Not as effective as high-ceiling diuretics (e.g., furosemide) for producing a diuresis. Patient Monitoring and Laboratory Tests Electrolytes should be monitored during chronic therapy. Formulations Chlorothiazide is available in 250- and 500-mg tablets, 50-
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認診斷與治療目標 確認精確產品與成分型態 確認腎功能與體液電解質狀態 確認併用藥與監測計畫 食用動物須另行確認殘留與停藥條件
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。