商品名:Sporanox and Itrafungol (available in Europe for cats)
Azole (triazole) antifungal drug. Itraconazole inhibits ergosterol synthesis in fungal cell membrane. Fungistatic. It is active against dermatophytes and systemic fungi, such as Blastomyces, Histoplasma, and Coccidioides. It is more potent against these Precautionary Information Adverse Reactions and Side Effects Hypotension is the primary adverse effect. It lowers arterial pressure. In horses, side effects may also include rubbing noses on objects, hyperexcitability, sweating, tachycardia, and restlessness. Contraindications and Precautions Do not use in hypotensive or dehydrated animals. Dru
Itraconazole is used to treat dermatophytes and systemic fungi, such as Blastomyces, Histoplasma, and Coccidioides. It also has been shown effective for treatment of Malassezia dermatitis, but doses are lower than for other infections (see dosing section). Although it has been used to treat infections caused by aspergillosis, efficacy has not been as good as with other antifungal drugs such as voriconazole or amphotericin B. Itraconazole is often considered the first choice for dermatophyte infections in cats.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
肝功能調整:Monitor liver enzymes; reduce dose if elevated
肝功能調整:Monitor liver enzymes; reduce dose if elevated
先確認精確活性物與成品,排除其他 azole、代謝物、人用或獸用不同製劑及調劑品互換。 再確認法域、物種、病原與感受性、診斷、感染部位與嚴重度、肝腎心臟及繁殖狀態和全部併用治療。 由獸醫師建立個案成品、途徑、方案、期間或終點、療效、安全、監測、停用、調劑與雙邊交互作用契約。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。