商品名:Cytoxan, Neosar, and CTX
Cytotoxic and anticancer agent. Cyclophosphamide belongs to the group of nitrogen mustards. They are alkylating agents (bifunctional alkylating agents) that alkylate various macromolecules but preferentially alkylate the N-7 of the guanine base of DNA. They are cytotoxic to cancer cells and are toxic to the rapidly dividing cells of the bone marrow. Cyclophosphamide must be metabolized to active 184 Cyclophosphamide Precautionary Information Adverse Reactions and Side Effects Cyclophosphamide is toxic to the bone marrow in a dose-dependent manner. After a single large bolus dose, the nadir of
Cyclophosphamide is used primarily as adjunct for cancer chemotherapy and as immunosuppressive therapy. Cyclophosphamide is probably the most potent of the nitrogen mustards. It is used in chemotherapy protocols for a variety of tumors, carcinomas, sarcomas, feline lymphoproliferative diseases, mast cell tumor, mammary carcinoma, and especially lymphoproliferative tumors (lymphoma). Cancer protocols such as cyclophosphamide, Oncovin, and prednisone (COP) and cyclophosphamide, hydroxydaunomycin, Oncovin, and prednisone (CHOP) incorporate cyclophosphamide as one of the agents. The other major us
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現有資料把不同腫瘤/免疫用途、MTD/metronomic、cycle/day、route、產品、BSA/體重與監測合成通用範圍。完成診斷、具名 protocol/version/cycle、產品/route、獨立劑量核對、CBC/urinalysis、累積曝露與 hazardous-handling gate 前,封鎖計算、處方及飼主量。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。