商品名：Lopurin, Zyloprim, and Allopur (Europe)
Purine analogue. Allopurinol decreases the production of uric acid by inhibiting enzymes responsible for uric acid synthesis. The other use of allopurinol is treating leishmaniasis. In parasites, allopurinol is metabolized to products that disrupt RNA synthesis and interfere with protein synthesis. Allopurinol does not eliminate Leishmania or cure the disease, but it may improve cutaneous lesions and induce remission.
Allopurinol is indicated to decrease formation of uric acid uroliths in at-risk animals. Allopurinol also is used to treat clinical signs associated with leishmaniasis. When used for leishmaniasis it is administered with pentavalent antimonial compounds such as meglumine antimonite (Glutamine) or sodium stibogluconate (Pentosan). With chronic treatment, allopurinol will produce progressive remission and improvement in clinical signs associated with leishmaniasis, which include decreasing the damaging effects of Leishmania on the animal’s kidneys by decreasing proteinuria and preventing deterio
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
核對母藥、鹽型、精確商品、濃度、法域與實際供應狀態 核對動物種類、品種、體重、精確診斷、疾病分期、肝腎與泌尿狀態 核對飲食、尿石成分、結晶與尿液監測、合併治療、抗藥性與復發計畫 核對所有併用藥、妊娠泌乳繁殖狀態、生產類別、食物鏈與必要救援門檻
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
2.7 hours