氯磺丙脲 Chlorpropamide

作用機轉

Sulfonylureas lower blood glucose concentrations in both diabetic and non-diabet­ic patients. The exact mechanism of action is not known, but these agents are thought to exert the effect primarily by stimulating the beta cells in the pancreas to secrete additional endogenous insulin. On­going use of the sulfonylureas appears to en Chlorpromazine will darken upon prolonged exposure to light; do not use solutions that are darkly colored or if precipitates have formed. A slight yellowish color will not affect potency or efficacy. Alkaline solutions will cause the drug to oxidize. The following products have been reported to be compatible when mixed with chlorpromazine HCl injection: all usual intravenous fluids, ascorbic acid, atropine sulfate, butorphanol tartrate, diphenhydramine, droperidol, fentanyl citrate, glycopyrrolate, heparin sodium, hydromorphone HCl, hydroxyzine HCl, lidocaine HCl, meperidine, metoclopramide, metaraminol bitartrate, morphine sul­fate, pentazocine lactate, promazine HCl, promethazine, scopolamine HBr, and tetracycline HCl. The following products have been reported as being incompatible when mixed with chlorpro­mazine: aminophylline, amphotericin B, chloramphenicol sodium succinate, chlorothiazide sodium, dimenhydrinate, methicillin sodium, methohexital sodium, nafcillin sodium, penicillin g potassium, pentobarbital sodium, phenobarbital sodium, and thiopental sodium. Compatibility is dependent upon factors such as pH, concentration, temperature, and diluent used; consult specialized references or a hospital pharmacist for more specific in­formation.