商品名：Diflucan and generic brands
Azole antifungal drug. Fungistatic. Fluconazole inhibits ergosterol synthesis in fungal cell membrane and has activity against dermatophytes, systemic fungi, and yeasts, including Candida, Coccidioides, and Cryptococcus spp.. However, it has weak activity against molds such as Aspergillus or Zygomycetes. Compared to other oral azole antifungals, fluconazole is absorbed more predictably and completely, even on an empty stomach. The half-life in dogs, cats, and horses is approximately 14-15, 13-25, and 38 hours, respectively.
Fluconazole is effective against dermatophytes, yeasts, and a variety of systemic fungi. In dogs, cats, horses, and exotic animals, it is used to treat systemic fungal infections, Fluconazole 317 F yeast infections, and dermatophytes, including Malassezia dermatitis. In cats it has been used to treat Cryptococcus. In dogs, it is not as active against coccidioidomycosis as other azole antifungal drugs, but it has been effective in some patients. Higher doses may be needed (e.g., 10 mg/kg q12h) for coccidioidomycosis. Because it is water soluble, it has been used to treat fungal cystitis.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
必須核對有效成分、精確製造商、成品、劑型、濃度、來源與調製狀態；不得假設不同人用或調製產品可互換。 必須由獸醫依物種、確切病原與感染部位、疾病嚴重度、器官功能、共病、併用藥、療效終點及復發風險個案評估。 犬、貓、馬、鳥、兔、其他特殊寵物與食用動物的證據必須分開，不得跨物種、途徑、疾病或劑型轉移。 若考慮 methadone、phenobarbital、cyclosporine 或其他併用藥，必須由臨床獸醫個案判讀並設定監測；本資料庫不得自動配對或宣告沒有交互作用。 肝臟、腎臟、藥物濃度、繁殖安全、過量、儲存、棄置、法規、食用動物殘留與停藥資訊都必須依精確患者與成品另行閉合。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
30 hours
renal