商品名：Buprenex (Vetergesic in the UK)
Opioid analgesic. Buprenorphine is a partial mu-receptor agonist and kappa-receptor antagonist. It is 25 to 50 times more potent than morphine. Buprenorphine may cause less respiratory depression than other opiates. The pharmacokinetics in dogs have been variable, depending on the study. The half-life in dogs has ranged from 4.5 hours to 9 hours, with a clearance from 5.4 to 24 mL/kg/min. In horses the half-life is 7 hours, with a clearance of 8 mL/kg/min. In horses the absorption from IM administration is highly variable (41%-93%).
Buprenorphine is an opiate analgesic that is used for pain control in dogs and cats. It has lower efficacy (lower ceiling) than pure mu-receptor agonists such as morphine. Buprenorphine has been shown to be effective in animal studies for treating postoperative pain. Duration of analgesia based on plasma values in animals is 3-4 hours, but it may be longer clinically because of slow dissociation from binding sites or longer half-life from CNS tissues and higher affinity for the mu-receptor. Duration of effect has not been established for all indications in well-controlled studies and has 86 Bu
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認精確產品、有效成分鹽型、效價基準、濃度、容器與司法管轄 確認物種、體重、年齡、手術與疼痛脈絡、既往鴉片暴露、呼吸與肝功能及所有併用藥 由獸醫師建立鎮痛評估、救援止痛、呼吸、循環、體溫、鎮靜與異常行為監測計畫 確認專業人員操作、管制藥品保存、曝露處置、剩藥與廢棄物流程
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
hepatic