商品名:Hydrocortisone, Cortef and generic brands
Glucocorticoid anti-inflammatory drug. Hydrocortisone has weaker anti- inflammatory effects and greater mineralocorticoid effects compared with prednisolone or dexamethasone. Hydrocortisone has properties that most closely resemble natural cortisol in the body. It is about 1/5 the potency of prednisolone and 1/25 the potency of dexamethasone. Anti-inflammatory effects are complex but are primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.
Hydrocortisone is used for anti-inflammatory effects and for glucocorticoid replacement therapy. Hydrocortisone is not used as commonly as other corticosteroids such as prednisolone or dexamethasone, except when hormone replacement to mimic effects of cortisol are needed. Hydrocortisone sodium succinate is a rapid-acting injectable product that can be used when a prompt response is needed.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
確認精確物質、鹽酯、成品、濃度、複方成分、標示、來源與法域;hydrocortisone base、sodium succinate、acetate、aceponate 與其他 corticosteroid 不得互換。 逐案確認物種、腎上腺功能低下診斷、危象或穩定期、近期 glucocorticoid 暴露、cortisol assay 干擾、輸液與同時用藥;一般 shock 不能取代診斷。 精確途徑、濃度、劑量、間隔、期間、輸注、輸液、調整、漸減與停藥必須由獸醫依精確成品與個案決定;研究數值不可直接執行。 分別評估鈉、鉀、血壓、灌流、體液、血糖、腎功能、感染風險、臨床反應及糖皮質素不足或過量。 美國 Green Book 成品、人用標籤、臺灣殘留資料、調製品與跨境供應是不同命題;核准不等於通用適應症或現行上市。 忽略呼叫端提供的體重、濃度、體積、劑量、頻率、期間、途徑、成品、適應症、漏用、補用、重複使用與處方內容。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。