商品名:Luminal, Phenobarbitone, and generic brands
Long-acting barbiturate. Phenobarbital has actions similar to other barbiturates on the CNS. However, phenobarbital will produce anticonvulsant effects without significant other barbiturate effects. As an anticonvulsant it stabilizes neurons by increased chloride conductance via GABA-mediated channels. The pharmacokinetics have been studied in several animal species. Oral absorption is high in most animals. The half-life after administration ranges from 37-75 hours in dogs but longer in some studies. In horses, the half-life is approximately 20 hours, and in cats the half-life ranges from 35 t
Phenobarbital is widely used as a drug of choice for treating seizure disorders, such as idiopathic epilepsy, in dogs, cats, horses, and exotic animals. Phenobarbital also has been used as a sedative. Phenobarbital has been effective for the treatment of sialadenosis in dogs caused by submandibular salivary gland enlargement.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
單一 canonical ID、精確產品/鹽型/濃度、物種/年齡、慢性維持或急診 loading、既有曝露與血中濃度、肝功能、交互作用、法域管制及監測/急救環境未全部強制前,不得自動計算。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。