商品名:Felbatol
Anticonvulsant. The action to treat seizures in animals may be via antagonism at the N-methyl-D-aspartate (NMDA) receptor and block effects of excitatory amino acids. The half-life in dogs is 5-6 hours, which may require frequent administration.
Felbamate is used to treat epilepsy in dogs when they are refractory to other anticonvulsants. It has been used in conjunction with other anticonvulsants. However, the use in animals has declined because of the availability of other drugs to treat refractory seizures such as levetiracetam, zonisamide, gabapentin, and pregabalin. Precautionary information Adverse Reactions and Side Effects Not documented with use in dogs. In people the most severe reactions have been hepatotoxicity and aplastic anemia. Contraindications and Precautions It may increase phenobarbital concentrations. Drug Interactions Possible interactions exist with drugs that either alter or are substrates for hepatic cytochrome P450 enzymes. See Appendix. It may increase phenobarbital concentrations if used concurrently. Fe
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
必須由熟悉難治型癲癇的獸醫確認診斷、發作型態、既往治療反應與目前所有藥物。 必須核對精確製品、濃度、劑型、來源、保存條件與是否為人用或調製製品。 必須在開始前評估血液、肝臟、腎臟與眼表狀態,並自行制定追蹤與停藥門檻。 必須逐一評估合併抗癲癇藥的雙向濃度與臨床風險,不可依賴自動交互作用配對。 不得把病例系列、共識、治療濃度敘述或人用標籤直接轉成通用犬用處方。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。