商品名:Keppra
Anticonvulsant. The mechanism of action is not certain, but it does not involve inhibitory neurotransmitters. It inhibits burst firing of neurons without affecting normal neuronal excitement. It does not undergo hepatic metabolism but may undergo metabolism that does not include cytochrome P450 enzymes. Elimination relies on renal clearance.
In dogs, levetiracetam has been used to treat seizures, especially those refractory to other anticonvulsants. In dogs, it has been considered a drug of choice as an add-on medication when patients are refractory to phenobarbital and bromide therapy. It often is used in combination with other anticonvulsants. Levetiracetam has been used to treat seizure disorders in cats at a dose of 20 mg/kg every 8 hours and found to be effective in some cases. In dogs the oral absorption is 100%, the half-life is 3-4 hours, and the volume of distribution is 0.4-0.5 L/kg. In cats the oral absorption is also 1
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
腎功能調整:Reduce dose in renal impairment
腎功能調整:Reduce dose in renal impairment
確認動物物種、體重、發作分類、病因、嚴重度與急診狀態。 確認確切 IR、XR、注射或複方產品、強度、完整性、賦形劑、品質與監管取得方式。 確認全部共同用藥、腎功能、妊娠或哺乳狀態及先前反應。 建立個案化起始、監測、調整、漏服、停藥、異常反應與急救轉診計畫。 逐一人工裁決藥對;受保護同儕不得由對側 none、evaluated 或 override 解除。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
4 hours