商品名:Paraplatin
Anticancer agent. Carboplatin is a second-generation platinum compound and is related to cisplatin. Action is similar to cisplatin. Its action is a bifunctional alkylating agent, which interrupts replication of DNA in tumor cells. It induces a non-cell cycle–dependent tumor cell lysis. Major route of elimination is via the kidneys. It has replaced cisplatin in some anticancer protocols because it may not be as toxic.
Carboplatin has been used for squamous cell carcinoma and other carcinomas, melanoma, osteosarcomas, and other sarcomas. When used in dogs, myelosuppression has been the most dose-limiting factor. Compared to cisplatin, carboplatin is better tolerated in cats and is preferred. However, bone marrow suppression is the dose-limiting toxicity in cats. 104 Carboplatin
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
必須先確認卡鉑本體與精確產品、濃度、容量、容器、賦形劑與標籤版本;物種、體重與體表面積方法;腫瘤組織型、部位、病期、分級、可測量或微小殘存病灶、手術狀態與治療目標;單藥或合併方案、途徑、給予細節、週期與累積暴露;既往化療與放療、血球與骨髓儲備、腎功能與其他器官狀態;最低點與恢復監測、延後或調整規則、感染與出血救援、過敏與外滲處置;併用藥與疫苗的精確雙邊評估;調製、個人防護、洩漏、排泄物與廢棄物處理;以及當地處方與額外標示使用規則。任何一項未閉合即不得由 runtime 建議。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal