商品名：Platinol
Anticancer agent. Cisplatin acts like a bifunctional alkylator of DNA but forms a reactive carbonium ion, and the cross-linking occurs around the platinum ion instead of an alkyl group. It preferentially binds to the N-7 of guanine and adenine bases. As a result of this reaction, interstrand and intrastrand cross-linking of DNA occurs. The result is inhibition of DNA synthesis. A related drug is carboplatin, which is a second-generation platinum compound used in patients who may not tolerate cisplatin.
Cisplatin is used for treating various solid tumors, including bronchiogenic carcinoma, osteosarcoma, transitional cell carcinoma, and mast cell tumors. It has been shown to be effective for increasing the survival of dogs that have undergone amputations for osteosarcoma. Small Animal Dosage Clarithromycin 159 C Instructions for Use To avoid toxicity, fluid loading before administration using sodium chloride should be performed. Antiemetic agents are often administered before therapy to decrease vomiting. For transitional cell and squamous cell carcinomas, doses used are 40 to 50 mg/m2 every 21 to 28 days. For osteosarcoma, it has been used at a dose of 70 mg/m2 every 21 days for four treatments. Patient Monitoring and Laboratory Tests Monitor renal function in treated animals. Monitor CBC
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先核對順鉑而非其他鉑類或遞送系統，並確認精確商品、濃度、稀釋液、容器與相容性。 確認物種；貓有致命性肺毒性證據，不得由通用紀錄放行。 確認腫瘤類型與分期、手術或放療脈絡、方案角色、週期及累積暴露。 確認腎功能、血球、電解質、水化與支持療法、聽覺神經及給藥部位監測。 依當地法規與院所危害藥品程序管理調製、防護、溢灑、廢棄物與排泄物。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。