商品名：EtoGesic (veterinary preparation) and Lodine (human
Like other NSAIDs, etodolac has analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAID is the cyclo-oxygenase enzyme (COX). The COX enzyme exists in two isoforms: COX-1 and COX-2. COX-1 is primarily responsible for synthesis of prostaglandins important for maintaining a healthy GI tract, renal function, platelet function, and other normal functions. COX-2 is induced and responsible for synthesizing prostaglandins that are important mediators of pain, inflammation, and fever. However, it is known that there is some crossover of COX-1 and COX-2 effects in some situations; and COX-2 activity is important for some biological effects. In dogs, etodolac has a half-life of 7.6 to 14 hours, depending on the study and feeding conditions.
Etodolac is indicated for treatment of osteoarthritis in dogs. It also is used as an analgesic and may be used for other painful conditions. Like other NSAIDs, etodolac is expected to reduce fever. Uses in cats have not been established. Etodolac has been used in some horses to relieve pain associated with abdominal surgery and to treat lameness (e.g., caused by navicular disease). Dose regimens are different for horses compared with other animals.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
兩項美國犬用獸藥皆已撤回。歷史犬骨關節炎標籤只供追溯；任何個案判斷前須確認精確產品／來源與法域、犬身分、口服或背肩 SC 路徑、年齡、水合、胃腸／腎／肝／出血／眼睛風險、共同用藥、基線檢驗與追蹤。貓一律不得計算。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
77%