商品名:Dobutrex
Adrenergic agonist. Dobutamine is a racemic mixture (R and S isomers) that has both beta1- and beta2-adrenergic activity. However, its clinical effects are caused by the relative cardioselective agonist activity on beta1 receptors. There are both agonist and antagonist effects on alpha-receptors, the clinical effects of which are uncertain. The primary advantage of dobutamine is that it produces positive inotropic effects without excessive tachycardia. The lack of tachycardia distinguishes it from other sympathomimetic agents. At appropriate infusion rates, dobutamine can improve contractility
Dobutamine is used primarily for the acute treatment of heart failure. It produces an inotropic effect without increasing heart rates. Short treatment regimens (e.g., 48 hours) can have a residual positive effect in some animals.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
Dobutamine 是依即時反應滴定的高警訊 IV CRI,公開證據依物種與情境而異,產品濃度錯配可超過十倍。必須先確認產品、濃度、適應症、血容量/收縮力、pump、連續 ECG/血壓及停止條件。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。