商品名：Neptazane
Methazolamide is a carbonic anhydrase inhibitor. Methazolamide, like other carbonic anhydrase inhibitors, produces a diuresis through inhibition of the uptake of bicarbonate in proximal renal tubules via enzyme inhibition. This action results in loss of bicarbonate in the urine and a diuresis. The action of carbonic anhydrase inhibitors results in urine loss of bicarbonate, alkaline urine, and water loss. Methazolamide, like other carbonic anhydrase inhibitors, also decreases formation of cerebrospinal fluid (CSF) by the choroid plexus and decreases the ocular fluid formation by decreasing bicarbonate secretion by the ocular ciliary body. This effect on aqueous humor formation decreases ocular pressure.
Methazolamide is rarely used as a diuretic any longer. There are more potent and effective diuretic drugs available, such as the loop diuretics (furosemide). Methazolamide, like other carbonic anhydrase inhibitors, is used primarily to lower intraocular pressure in animals with glaucoma. Its duration is relatively short in dogs, in which more frequent administration may be required to maintain low ocular pressure. Methazolamide is used more often than acetazolamide for this purpose because it is more effective and easily available. However, other regimens are commonly used for the treatment of glaucoma compared to the carbonic anhydrase inhibitors. Methazolamide, like other carbonic anhydrase inhibitors, is sometimes used to produce more alkaline urine for management of some urinary calcul
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