商品名：Reglan and Maxolon
Prokinetic drug. Antiemetic. Metoclopramide stimulates motility of upper GI tract and is a centrally acting antiemetic. The mechanism of action of metoclopramide is not completely understood. Among the proposed mechanisms is stimulation of 5-HT4 (serotonin) receptors or an increase in the release of acetylcholine in the GI tract, possibly through a prejunctional mechanism. It also has anti-dopamine (D2) action. It inhibits gastric relaxation induced by dopamine, thus enhancing the cholinergic responses of gastric smooth muscle to increase motility. It also increases the tone of the esophageal
Metoclopramide is used primarily for gastroparesis and treatment of vomiting. It is not effective for dogs with gastric dilation. Because this drug transiently increases prolactin secretion, there has been interest in using this drug for treating agalactia in animals, but efficacy has not been determined. In horses, it has been used to treat intestinal postoperative ileus, but adverse effects have limited the use. In people, metoclopramide has been also used to treat hiccups and lactation deficiency.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認精確成品、鹽型、水合型態、強度基準與法域。 確認物種、年齡、生殖狀態、診斷、嚴重度與胃腸出血、機械性阻塞或穿孔。 確認途徑、治療意圖、器官功能、癲癇與其他神經病史、心血管與麻醉情境。 逐項核對所有併用藥、監測計畫、停止與救援規則、食用動物與競賽身分。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal