商品名：Emend
Aprepitant is a centrally acting antiemetic. Aprepitant is a substance P/neurokinin 1 (NK1) receptor antagonist, similar to maropitant (Cerenia). It is used primarily with drugs known to be highly emetic, such as cisplatin. This drug is effective because chemotherapy drugs and other emetic stimuli release NK1, which is highly emetic. It also blocks vomiting from other stimuli. The use in small animals has been somewhat limited because of the high expense and limited formulations for animals. In dogs, aprepitant is extensively metabolized after administration.
Aprepitant is an effective antiemetic for people, particularly when used to treat vomiting associated with cancer chemotherapy. It may be used with corticosteroids Ascorbic Acid 49 A (dexamethasone) and serotonin (5HT3) antagonists. However, despite its broad effects to decrease vomiting in people, there are no reports of effective use in dogs or cats. Instead, a similar-acting drug, maropitant (Cerenia), is used in dogs and cats and produces similar antiemetic effects.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
公開資料未確認具物種、適應症、途徑、頻率與療程的犬貓臨床 aprepitant 方案；不得將人用固定劑量、犬實驗代謝資料或 maropitant 劑量換算套用。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。