Dolasetron exerts its anti-nausea and antiemetic actions by selectively antagonizing 5-hydroxytryptamine3 (5-HT3) receptors. These receptors are found primarily in the CNS chemoreceptor trigger zone, on vagal nerve terminals and enteric neurons in the dolasetron mesylate 319 GI tract. Chemotherapy induced vomiting is believed to be caused principally by serotonin release from the mucosal enterochromaffin cells in the small intestine.
Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
公開資料可確認身分、人用產品與法規邊界、一項小型陰性貓 PK／PD 研究、犬 PK 與非臨床危害訊號，以及一次多藥癌症試驗的附帶用藥；但無法建立一般犬貓劑量、頻率、途徑、產品、臨床療效率、副作用發生率、交互作用規則或生殖安全結論。所有數值卡皆只留在稽核檔。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。