商品名:Clavabactin, Clavaseptin, Clavucil, Clavudale, Combisyn, Kesium, Nisamox, Noroclav, Synulox, Augmentin*
Amoxicillin binds to penicillin-binding proteins involved in bacterial cell wall synthesis, thereby decreasing cell wall strength and rigidity, affecting cell division, growth and septum formation. The addition of the beta-lactamase inhibitor clavulanate increases the antimicrobial spectrum against those organisms that produce beta- lactamase, such as Staphylococcus and Escherichia coli.
Active against Gram-positive and Gram-negative aerobic organisms and many obligate anaerobes. Penicillinase-producing Escherichia coli and Staphylococcus are susceptible, but difficult Gram-negative organisms such as Pseudomonas aeruginosa and Klebsiella are often resistant. Dose and dosing interval will be determined by infection site, severity and organism. The predominant bacterial infections in reptiles are Gram-negative and many are resistant to penicillins.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
確認成品、持有人、申請或授權號及目前法域狀態 確認兩種活性成分、各自鹽型、活性換算、強度與比例 確認物種、體況、感染部位、病原與藥敏 確認途徑、劑型、時程、療程、保存與復溶條件 評估過敏史、腎肝功能、懷孕泌乳與抗菌藥管理需求 逐案複核所有併用藥,不依賴自動無互動訊息
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。