商品名:Imidazole, Carboxamide*, Dacarbazine*, DTIC*
Methylates nucleic acids and inhibits DNA, RNA and protein synthesis.
Management of lymphoproliferative diseases (e.g. relapsed lymphoma), melanoma and soft tissue sarcoma. Use with caution in patients with renal or hepatic insufficiency. Can cause severe pain and extensive tissue damage with extravasation, and therefore must be administered via a preplaced i.v. catheter.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
D0190 Dactinomycin 與 D0020 Actinomycin-D 是同一活性成分,且現行 100/200/500 mg 製劑與真實 500 mcg 小瓶相差千倍。在 canonical merge、物種/腫瘤/protocol、精確產品/濃度/IV、BSA 與 mg/mcg 雙人核對、CBC/器官功能、radiation/共用藥、extravasation 與 hazardous-drug gates 完成前,封鎖計算、處方與飼主劑量。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。