商品名：Dramamine (Gravol in Canada)
Antihistamine (H1-blocker). Diphenhydramine is the active moiety of dimenhydrinate. Similar to other antihistamines, it acts by blocking the H1 receptor and suppresses inflammatory reactions caused by histamine. The H1 blockers have been used to control pruritus and skin inflammation in dogs and cats; however, success rates in dogs have not been high. Commonly used antihistamines include clemastine, chlorpheniramine, diphenhydramine, and hydroxyzine. Dimenhydrinate is converted to active diphenhydramine. Dimenhydrinate also has central-acting antiemetic properties, possibly by acting on the vomiting center or via the chemoreceptor- trigger zone (CRTZ).
Dimenhydrinate is used to prevent allergic reactions and for pruritus therapy in dogs and cats. However, success rates for treatment of pruritus have not been high. In addition to the antihistamine effect for treating allergies, dimenhydrinate, like other antihistamines, acts as an antiemetic via the drug effects on the centers that control vomiting in animals. Antihistamines used as antiemetics are administered for motion sickness, vomiting induced by chemotherapy, and GI disease that stimulates vomiting.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認動物種類、診斷與治療目標，不將犬動暈症證據直接套用於貓。 確認確切產品、有效成分、含量基準、劑型、賦形劑、所在法域及現行標示版本。 審查青光眼、癲癇、心血管、呼吸、甲狀腺、攝護腺、腸胃與泌尿阻塞、肝腎功能、懷孕哺乳及所有同時用藥。 法國產品標示、台灣人用藥品類別及美國人用標籤必須各自獨立判讀。 在產品版本衝突與貓動暈症證據衝突未人工裁決前，不產生處方或計算結果。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。