Injectable gold compounds have antiinflammatory, antirheumatic, immunomodulating, and antimicrobial ( _in vitro_ ) effects. The exact mechanisms for these actions are not well understood. Gold is taken up by macrophages where it inhibits phagocytosis and may inhibit lysosomal enzyme activity. Gold also inhibits the release of histamine, and production of prostaglandins. While gold does have antimicrobial effects _in vitro_, it is not clinically useful for this purpose.
Gonadorelin is indicated (approved) for the treatment of ovarian follicular cysts in dairy cattle. Additionally, gonadorelin has been used in cattle to reduce the time interval from calving to first ovulation and to increase the number of ovulations within the first 3 months after calving. This may be particularly important in increasing fertility in cows with retained placenta. In dogs, gonadorelin has been used experimentally to help diagnose reproductive disorders or to identify intact animals versus castrated ones by maximally stimulating FSH and LH production. It has also been used experimentally in dogs to induce estrus through pulsatile dosing. While apparently effective, specialized administration equipment is required for this method. Gonadorelin has been used in cats as an alternate therapy to FSH or hCG to induce estrus in cats with prolonged anestrus. In Europe, a synthetic analogue buserelin has been used in horses to stimulate cyclic estrus. Its efficacy rates poorly when compared to an artificial light program, however. In human medicine, gonadorelin has been used for the diagnosis of hypothalamic-pituitary dysfunction, cryptorchidism, and depression secondary to prolonged severe stress.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
必須核對確切金化合物、配位體、活性金或化合物質量基準、產品名稱、規格與賦形劑。 必須核對物種、疾病、診斷、途徑、共同治療、法域、核准與實際供應狀態。 人用風濕病標示、歷史獸醫病例、毒理研究與不同金化合物不得彼此換算。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal