商品名：Cuprimine and Depen
Penicillamine is also called 3 mercaptovaline. It is a chelating agent for lead copper, iron, and mercury. When used to treat copper toxicity, it helps to solubilize copper in the cells to allow for more rapid urinary excretion. Treated animals should have increased copper urinary excretion. Other drugs that have been used as chelating agents include tetrathiomolybdate, trientine, and zinc. Penicillamine also has anti-inflammatory properties. It inhibits collagen cross-linking by making it more susceptible to enzyme degradation. This antifibrotic property may contribute to its positive effect
Penicillamine has been used in people to treat rheumatoid arthritis. In animals it is used primarily for treatment of copper toxicity and hepatitis associated with accumulation of copper. Treatment duration for animals with copper-storage hepatic disease may require 2-4 months. It also has been used to treat cystine calculi. Although it may inhibit collagen and reduce fibrosis in patients with hepatic disease, this effect has been disappointing in clinical patients. There is no clear demonstration that it is efficacious for this indication.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
犬銅相關肝病、犬貓鉛中毒及低優先犬胱胺酸尿石方案不可互換；鳥類、小反芻獸、通用貓用與 intrathecal 資料均未獲支持或受污染。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal