商品名：Butazolidin, PBZ, and generic brands
Phenylbutazone and other NSAIDs produce analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAIDs is the cyclo-oxygenase enzyme (COX). The COX enzyme exists in two isoforms: COX-1 and COX-2. COX-1 is primarily responsible for synthesis of prostaglandins important for maintaining a healthy GI tract, renal function, platelet function, and other normal functions. COX-2 is induced and responsible for synthesizing prostaglandins that are important mediators of pain, inflammation, and fever. However, it is known that there is some crossover of COX-1 and COX-2 effects in some situations, and COX-2 activity is important for some biological effects. Phenylbutazone, using in vitro assays, is a nonselective inhibitor of COX-1 and COX-2. Phen
The major use of phenylbutazone is in horses for musculoskeletal pain and inflammation, arthritis, soft tissue injury, and racing injuries. It is approved in both dogs and horses. The duration of action in horses after a single administration is approximately 24 hours. Phenylbutazone is approved for use in dogs (and cats in Europe); however, the use in small animals is not common because of the availability of other drugs.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
未核對精確產品、濃度、物種、route、法域、療程、併用藥、非食用馬身分及監測計畫前，停止所有自動輸出。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。