商品名：Glyceryl guaiacolate, Guaiphenesin, Geocolate,
Guaifenesin, which is also known as glyderyl guaiacolate, is a compound that has been an older, traditional therapy for treating cough in people, although the efficacy has been questioned for this effect. For respiratory disease, it is administered orally to produce an expectorant effect. This effect is presumably via stimulation of vagal transmission to produce more viscous bronchial secretions. As an anesthetic adjunct, it is used as a preanesthetic with barbiturates and other drugs. It is a central-acting skeletal muscle relaxant and causes sedation and relaxation via depression of nerve transmission. Pharmacokinetic information is limited, but half-life in ponies is 60-84 minutes. Duration of action in horses is approximately 30 minutes.
Guaifenesin is administered IV (particularly in large animals) as an adjunct to anesthesia and orally in animals as an expectorant. Historically, it also has been used as an analgesic and antipyretic. Most often it is used prior to induction of general anesthesia in horses, but it also has been used in other species. Supporting data for an expectorant effect are lacking. It may increase the volume and reduce the viscosity of secretions in the trachea and bronchi. It may also facilitate removal of secretions. 356 Guaifenesin Instructions for Use For anesthetic purposes, 5% guaifenesin is prepared from powder (50 g/L) dissolved in sterile water. It dissolves more readily if the water is warm. Infusion of 110 mg/kg can produce transient recumbency, but usually it is administered with other ag
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
在法域、物種與供食狀態、精確產品／成分／濃度／溶媒、IV 途徑與導管、完整平衡麻醉方案、鎮靜／鎮痛、輸注終點／速率、心肺監測及溶血風險全部確認前，封鎖通用計算。移除污染的貓 units/kg SQ／IM 劑量，也不得把口服祛痰或犬／反芻獸研究數值轉成可執行療程。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal