商品名：Avelox
Fluoroquinolone antibacterial. Moxifloxacin, like other quinolones, inhibits DNA gyrase and prevents bacterial cell DNA and RNA synthesis. Moxifloxacin is bactericidal with broad antimicrobial activity. It has a chemical structure slightly different from older veterinary fluoroquinolones (8 methoxy substitution). As a result of this modification, this newer generation of drugs, such as moxifloxacin, has Moxifloxacin 529 M greater activity against gram-positive bacteria and anaerobes than the veterinary fluoroquinolones (enrofloxacin, orbifloxacin, danofloxacin, and marbofloxacin).
Moxifloxacin, although a human drug, has been used in small animals for treatment of infections refractory to other drugs, including skin infections, pneumonia, and soft tissue infections. The spectrum of activity includes gram-positive cocci and anaerobic bacteria that may be resistant to other quinolones. Because other veterinary fluoroquinolones are preferred for initial use (enrofloxacin, orbifloxacin, danofloxacin, and marbofloxacin), moxifloxacin use is not common. Data for use in small animals are sparse and regimens are primarily extrapolated from the human label. In horses it has been administered at 5.8 mg/kg/day for 3 days. Although pharmacokinetics were favorable in horses, it caused diarrhea that may present a risk.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先核對實際產品、鹽型、完整濃度與全身性或眼用製劑身分。 確認物種、年齡與生長狀態、感染部位、病原菌、培養與感受性結果，以及是否已有較窄或具獸醫核准的替代藥。 若考慮全身性使用，先評估心律、QT 風險、電解質、神經與癲癇病史、肝腎狀態及所有併用藥。 若考慮眼科使用，先由獸醫眼科檢查感染深度、角膜完整性、培養結果與實際製劑，禁止把眼用製劑當成其他製劑。 確認妊娠、泌乳與食物鏈身分；美國食用動物的標示外氟喹諾酮使用不得開啟。 不得由人用標示、健康動物藥動、QT 模型、體外 MIC 或其他氟喹諾酮資料自動產生處方。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。