商品名:Noroxin
Fluoroquinolone antibacterial drug. Norfloxacin acts via inhibition of DNA gyrase in bacteria to inhibit DNA and RNA synthesis. It is a bactericidal with a broad spectrum of activity. Sensitive bacteria include Staphylococcus, Escherichia coli, Proteus, Klebsiella, and Pasteurella. Pseudomonas aeruginosa is moderately sensitive. However, norfloxacin is not as active as other drugs in the fluoroquinolone group.
Norfloxacin has been replaced by other veterinary fluoroquinolones because they have more favorable pharmacokinetics and improved spectrum of activity. However, it has been used to treat a variety of infections, including respiratory, urinary tract, skin, and soft tissue infections.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
未驗證犬貓常規臨床方案。犬 11–22 mg/kg q12h 與 20 mg/kg q12h 只是小型健康犬 PK/PD 暴露,不是療效方案;貓沒有直接可確認方案。培養/MIC、精確產品、物種、成長、腎功能、水分、交互作用與監測 gate 完成前封鎖。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。