商品名：Pralidoxime*
Reactivates the cholinesterase enzyme damaged by organophosphate (OP) and allows the destruction of accumulated acetylcholine at the synapse to be resumed. In addition, pralidoxime detoxifies certain OPs by direct chemical inactivation and retards the ‘ageing’ of phosphorylated cholinesterase to a non-reactive form.
Management of OP toxicity. Most effective if given within 24 hours. Pralidoxime does not appreciably enter the CNS, thus CNS toxicity is not reversed. If given within 24 hours of exposure, treatment is usually only required for 24–36 hours. Respiratory support may be necessary. Treatment of OP toxicity should also include atropine. Use at a reduced dose with renal failure.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
這是院內有機磷中毒急救藥；必須先確認確切鹽型／產品／濃度、物種、毒物及 aging、途徑與注射速率、atropine、呼吸支持及腎功能，故不提供通用計算。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。