商品名:Streptozotocin and Zanosar
Streptozocin (also known as streptozotocin) is an agent with specific effects on pancreatic beta cells. It is a nitrosourea alkylating agent with a specific cytotoxic effect on the pancreatic cells. There is selective uptake into pancreatic beta cells. It can produce diabetes mellitus in normal animals, but it is used primarily for treating insuloma tumors in animals. Occasionally it has been used as a cytotoxic agent for treating other tumors in humans (e.g., lymphoma, sarcomas), but these uses are not reported for animals. Streptozocin has a rapid half-life in animals but metabolites may be active. Metabolites rapidly cross the blood–brain barrier.
In animals, streptozocin is used primarily for treating insulin-secreting tumors (insulinoma). It has been used in experimental animals to create models of diabetes mellitus.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
犬胰島素瘤資料僅來自小型方案研究,效益不確定;窄治療窗、長時間輸液、低血糖、永久糖尿病、不可逆腎小管毒性、外滲與危害藥物處理都不能由通用計算器安全執行。未找到貓臨床療程。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。