See the Ticarcillin monograph for information on ticarcillin. By adding clavulanate, ticarcillin’s efficacy can be extended against betalactamase-producing strains of otherwise resistant _E. coli_, _Pasturella_ spp., _Staphylococcus_ spp., Klebsiella, and Proteus. Clavulanic acid acts by competitively and irreversibly binding to beta-lactamases, including types II, III, IV, and V, and penicillinases produced by Staphylococcus. Type I beta-lactamases that are often associated with _E. coli_, Enterobacter, and Pseudomonas are not generally inhibited by clavulanic acid. Clavulanic acid has only weak antibacterial activity when used alone and at present is only available in fixed-dose combinations with either amoxicillin (oral) or ticarcillin (parenteral). Unlike sulbactam or tazobactam, clavulanic acid (clavulanate) can induce chromosomal beta-lactamases. Synergy against _Pseudomonas aeruginosa_ can occur when used with an aminoglycoside, but the drugs cannot be mixed together (see Drug Interactions).
_Telazol_ ® is indicated for restraint or anesthesia combined with muscle relaxation in cats, and for restraint and minor procedures of short duration (≈30 minutes) which require mild to moderate analgesia in dogs. Although not officially approved, it has been used also in horses and many exotic and wild species.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
56 張數值證據卡全部 non-executable。live 內容混合單方與 Timentin 複方,並把犬、貓、成馬、幼駒的研究性全身用法及犬耳用法匯入通用執行層。現行可驗證的美國獸醫核准只限 Ticillin 精確產品、母馬發情期、子宮內途徑、β 溶血性鏈球菌子宮內膜炎與非供人食用馬。通用 API 無法聯合強制這些條件、完整產品仿單、無菌操作、培養/藥敏、腎臟/電解質/出血監測及法域,因此禁止計算、處方、飼主數值與跨產品/跨物種執行。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal