商品名:Zebeta
Bisoprolol is a synthetic beta1-selective beta-adrenergic receptor blocker with a low affinity for beta2-receptors in bronchial smooth muscle, blood vessels, and fat cells and no intrinsic sympathomimetic activity. Typical cardioselective effects include lower heart rate, decreased cardiac output, and inhibition of renin release by kidneys. At higher doses it will lose beta1 selectivity and also inhibit some beta2 receptors to affect bronchial and vascular smooth muscle. Clearance in dogs is balanced (60% metabolized by the liver and 40% excreted unchanged), distinguishing bisoprolol from lipophilic beta blockers such as carvedilol and metoprolol and hydrophilic beta blockers like atenolol. In dogs, bisoprolol has high and consistent oral absorption (91%) and a half-life of 4 hours. Althou
Bisoprolol is a beta1 blocker that is somewhat cardioselective and therefore is indicated for conditions that require a reduction in heart rate, heart conductivity, or contractility. Such conditions include tachyarrhythmias and atrial fibrillation. In people it is used to treat hypertension, but this use has not been explored in animals. Bleomycin Sulfate 75 B
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
犬公開學術處方集雖列口服範圍,但適應症、心率、血壓、ECG/Holter、收縮功能、灌流與心衰穩定度必須共同決定起始與調整;小型 DCM 研究顯示較高起始暴露可使血壓與心肌功能惡化。故不開放無條件計算;貓劑量未建立並完全封鎖。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。