Diminazene’s exact mechanism of action is not well understood. With Babesia, it is thought to interfere with aerobic glycolysis and DNA synthesis. Diminazene may not completely eradicate the organism but because it is slowly metabolized, suppression of recurrence of clinical signs or prophylaxis can be attained for several weeks after a single dose.
In veterinary medicine, dimenhydrinate is used primarily for its antiemetic effects for vomiting and in the prophylactic treatment of motion sickness in dogs and cats. Dimenhydrinate may be useful as an adjunctive treatment for feline pancreatitis. As dimenhydrinate is often thought of as “half-strength diphenhydramine” it can be employed whenever a histmine-1 blocker is desired. 300 dimenhydrinate
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
本藥治療指數窄,犬在單次 3.5 mg/kg 後也有致死性神經毒性病例系列。南非現行 Berenil R.T.U. 對犬明示只注射一次且不得超量或重複,與專案日前可執行的 24 小時後重複或每兩週重複相衝突。貓 cytauxzoonosis 的公開證據只有小型、異質或慢性帶原者失敗研究,歐盟建議更明示因不良反應不建議用於貓。又有單方、與 phenazone 複方及即用液/復溶粉的製劑差異,法規、寄生蟲種、物種、途徑與食用動物殘留規則也各不相同,所有數字必須先封鎖。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。