商品名:Dectomax
Antiparasitic drug. Avermectins (ivermectin-like drugs) and milbemycins (milbemycin, doramectin, and moxidectin) are macrocyclic lactones and share similarities, including mechanism of action. These drugs are neurotoxic to parasites by potentiating glutamate-gated chloride ion channels in parasites. Paralysis and death of the parasite is caused by increased permeability to chloride ions and hyperpolarization of nerve cells. These drugs also potentiate other chloride channels, including ones gated by GABA. Mammals ordinarily are not affected, because they lack glutamate-gated chloride channels, and there is a lower affinity for other mammalian chloride channels. Because these drugs ordinarily do not penetrate the blood-brain barrier, GABA-gated channels in the CNS of mammals are not affecte
Doramectin is used for treatment or prevention of GI parasite (nematode) infections in livestock, lice infestation, lungworm infection, and treatment of scabies. There are reports of a single injection (200-300 mcg/kg) used in cats for treatment of notoedric mange (infections from the mite Notoedres cati).
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
確認活性成分、實際成品、濃度、製劑、載體、包裝與標籤版本。 確認物種、生產類別、體重、寄生蟲與階段、診斷、適應症及途徑。 食品動物須核對司法管轄、完整核准、條件核准或緊急授權、屠宰停藥、棄乳、反芻前犢牛與小牛肉限制。 犬隻暴露須把標籤致命警告、個體 ABCB一狀態、實際劑量與神經症狀納入風險評估,不得以品種清單取代。 依寄生蟲與疾病情境安排療效、抗藥性、顯微鏡、內視鏡、檢驗及神經監測。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。