商品名：Nuflor, Nuflor Gold, Resflor (flunixin and florfenicol)
Florfenicol is a thiamphenicol derivative with the same mechanism of action as chloramphenicol (inhibition of protein synthesis). However, it is more active than either chloramphenicol or thiamphenicol. Florfenicol has a broad spectrum of antibacterial activity that includes all organisms sensitive to chloramphenicol, gram-negative bacilli, gram-positive cocci, and other atypical bacteria such as mycoplasma. Florfenicol is highly lipophilic, which provides high enough concentrations to treat intracellular pathogens and cross some anatomical barriers (penetration across the blood–brain barrier in cattle is 46%). The half-life of florfenicol is 2-3 hours in cattle after IV administration, but it is prolonged (18 hours) after IM injection. In dogs the half-life is shorter, with values of 1.1
Because florfenicol is a derivative of chloramphenicol, it has been used in situations in which chloramphenicol is unavailable or illegal. (Chloramphenicol is illegal to use in food animals in the United States.) Florfenicol has been shown to be effective for treatment of bovine respiratory disease (BRD) in cattle associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni (formerly Haemophilus somnus). Administration of florfenicol (40 mg/kg once SQ) at time of arrival to the feedlot decreased the incidence of BRD. It also is used for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, and infectious Florfenicol 315 F pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus and for treatment of
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先核對精確成品、申請號、單方或複方、濃度、劑型、法域與目前供應狀態，不得只看 florfenicol 成分名。 逐案確認物種、生產類別、感染診斷、培養與藥敏、病原、器官狀態、同時用藥與抗菌藥管理目標。 食品動物必須另外核對途徑、飼料或飲水系統、VFD 或處方、繁殖限制、殘留與依現行規則建立的停藥計畫。 犬耳用複方、牛用 florfenicol-flunixin 複方、健康犬 PK、體外資料與食品動物標示均不得轉為犬貓單方全身性處方。 由獸醫建立療效、耐受、食慾飲水、局部反應、血液學、肝腎與再評估計畫；不得由呼叫端數值自動生成。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
18 hours