商品名：Primaxin
Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. Action on the cell wall is similar to other beta-lactams, which is to bind penicillin-binding proteins (PBP) that weaken or interfere with cell wall formation. The carbapenems are capable of binding to a specific PBP (PBP-1) that results in more rapid lysis compared to other beta-lactams. This results in greater bactericidal activity and a longer postantibiotic effect. Carbapenems have a broad spectrum of activity and are among the most active of all antibiotics. Spectrum includes gram-negative bacilli, including Enterobacteriaceae and Imipenem + Cilastatin 379 I Pseudomonas aeruginosa. It also is active against most gram-positive bacteria, except methicillin-resistant strains of S
Imipenem is used primarily for infections caused by bacteria resistant to other drugs. Imipenem is especially valuable for treating resistant infections caused by Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. Although active against gram-positive bacteria such as staphylococci (but not methicillin- resistant strains), other less expensive drugs should be used for gram-positive infections. Meropenem and doripenem are newer drugs in the class of carbapenems and have some advantages with respect to activity and convenience of administration.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先確認所在法域；歐盟現行法律禁止 carbapenem 用於動物，舊指南不得覆蓋此禁令。 在其他法域也須確認精確產品、成分鹽型與水合狀態、活性等量、比例、濃度、稀釋液、容器、病患物種、感染部位、病原與有效感受性解讀。 必須由獸醫團隊評估腎功能、神經與癲癇風險、過敏史、共病、其他藥物、臨床反應及抗菌藥物管理要求。 研究數值與人用標示只能作為來源卡，不得啟動計算器、處方或飼主數字指示。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal