Antihistamines (H1-receptor antagonists) competitively inhibit histamine at H1 receptor sites. They do not inactivate or prevent the release of histamine, but can prevent histamine’s action on the cell. Besides their antihistaminic activity, these agents also have varying degrees of anticholinergic and CNS activity (sedation). Tripelennamine is considered to have moderate sedative activity and minimal anticholinergic activity when compared to other antihistamines.
Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
API 無法同時強制鹽酸鹽／濃度基準、精確產品與申請號、現行上市狀態、法域、物種／類別、途徑、適應症、食品停藥、競賽、生殖、合併用藥與監測，因此 40 張數值卡均不可執行；naloxone opioid-reversal 污染已由 overlay 清空。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。